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Updated in 2019/2/6 下午 12:02:25      Viewed: 162 times      (Journal Article)
Pediatric pulmonology (2019)

Interleukin-4 -590C/T gene polymorphism in Egyptian children with acute lower respiratory infection: A multicenter study.

Ahmed A Emam , Mohamed M M Shehab , Mayy A N Allah , Mohamed A Elkoumi , NourEldin M Abdelaal , Amira A A Mosabah , Mervat T Zakaria , Ashraf M Sherif , Mohammed M Soliman , Rania M H El-Kaffas , Heba Abouzeid , Mohammed A Abdou , Nermin Abdalmonem , Heba R Abdelbaset , Soma A Mohamed , Attia A Soliman , Shaimaa S A Elashkar , Mohamed S Hegab , Atef M Khalil , Alsayed Abdel-Aziz , Heba G Anany , Hossam E Salah , Adel M Abdou , Naglaa A Elshehawy , Hany A A Elbasyouni , Sahbaa F M Hafez , Doaa A Abo-Alella , Maggie M Fawzi , Samar S Morsi
ABSTRACT
Acute lower respiratory infection (ALRI) is the leading cause of child mortality, especially in the developing world. Polymorphisms in the interleukin 4 (IL-4) gene have been linked to a variety of human diseases.To investigate whether the IL-4 -590C/T (rs2243250) polymorphism could be a genetic marker for susceptibility to ALRIs in young Egyptian children.This was a multicenter study conducted on 480 children diagnosed with pneumonia or bronchiolitis, and 480 well-matched healthy control children. Using PCR-RFLP analysis, we genotyped a -590C/T (rs2243250) single nucleotide polymorphism of the IL-4 gene promoter, meanwhile the serum IL-4concentration was measured by ELISA.The frequency of the IL-4 -590 T/T genotype and T allele were overrepresented in patients with ALRIs in comparison to the control group (OR = 2.0; [95% confidence interval [CI]: 1.38-2.96]; for the T/T genotype) and (OR: 1.3; [95%CI: 1.07-1.56]; for the T allele; P < 0.01). The IL-4 -590 T/T genotype was associated with significantly higher mean serum IL-4 concentration (58.7 ± 13.4 pg/mL) compared to the C/T genotype (47.6 ± 11 pg/mL) and the C/C genotype (34.8 ± 9.6 pg/mL); P < 0.01.The IL-4 -590C/T (rs2243250) polymorphism may contribute to susceptibility to ALRIs in young Egyptian children.
DOI: 10.1002/ppul.24235      ISSN: 8755-6863