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Updated in 2020/5/8 下午 09:11:24      Viewed: 36 times      (Journal Article)
Microbes and infection 2 (13): 1567-78 (2000)

Diagnosis of defects in the type 1 cytokine pathway.

D A Lammas , P Drysdale , A Ben-Smith , J Girdlestone , D Edgar , D S Kumararatne
Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.
DOI: 10.1016/s1286-4579(00)01313-7      ISSN: 1286-4579