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Updated in 2019/12/17 下午 06:52:02      Viewed: 377 times      (Journal Article)
British journal of haematology 116 (2): 497-9 (2002)

Non-myeloablative bone marrow transplantation in an adult with Wiskott-Aldrich syndrome.

Hilary J Longhurst , David Taussig , Tanzina Haque , Denise Syndercombe-Court , Jamie Cavenagh , J David Edgar , Matthew R Helbert
Early bone marrow transplant is now standard treatment for infants with severe immunodeficiencies such as Wiskott-Aldrich Syndrome (WAS), but results in older children and adults are poor. Non-myeloablative transplant has shown promise in the treatment of older children, who are likely to have active infections and organ damage. We describe a non-myeloablative transplant of a 26-year-old man with WAS, undertaken because of severe infections and vasculitis. Partial engraftment and immunorestoration were achieved. The patient is well 1 year post transplantation.
DOI: 10.1046/j.1365-2141.2002.03269.x      ISSN: 0007-1048